Pharma Test Announces Improved PT-DDS4 Media Preparation and Degassing System

Pharma Test Announces Improved PT-DDS4 Media Preparation and Degassing System

Pharma Test Announces Improved PT-DDS4 Media Preparation and Degassing System

The optimized PT-DDS4 features a new tank design with a sloped bottom instead of a flat one to simplify the emptying of the device for cleaning without leaving any remaining liquid in the tank. For this reason as well, the pipe outlet is now longer und curved. The new tank can still hold enough medium for at least two 12-position dissolution testing instruments. The PT-DDS4 now also includes bigger and more sturdy wheels to move the instrument from one working space to the next – no matter what the floor condition might be.

Technical drawings of the new and improved PT-DDS4 with an optimized new tank and improved pipe outlet. The wheels are also bigger and better for easy maneuvering around wherever the PT-DDS4 needs to be and no matter the floors condition

All improvements for the PT-DDS4 Media Preparation and Degassing System

  1. Bigger, sturdier wheels for easy maneuvering: The new PT-DDS4 is now based on bigger, sturdier wheels which make it easier to move the instrument around from one working space to another no matter what the floor condition may be. Like in the previous PT-DDS4 model the newer version also comes with brakes.
  2. New tank design: The new PT-DDS4 features a new tank design with a sloping instead of a flat bottom to simplify emptying the device for cleaning. Leaving no residue behind that would be difficult to remove. This change came through customer feedback who had difficulties to remove all of the medium out of the tank. The tank holds enough medium for at least two 12-position dissolution testers or enough for 24 vessels with one de-aeration cycle.
  3. Optimized pipe outlet: The pipe outlet is now longer and curved. This change was also done so you can easily drain the complete media from the vessel without residues.
Old vs. new: The old tank on the left with a flat bottom, the new and improved tank on the right with the sloping bottom which simplifies the draining

Old vs. new: The old tank on the left with a flat bottom, the new and improved tank on the right with the sloping bottom which simplifies the draining

Old vs. new: The old pipe outlet on the left, the new longer and curved pipe outlet on the right which also simplifies removing the medium without inconvenient residue

Old vs. new: The old pipe outlet on the left, the new longer and curved pipe outlet on the right which also simplifies removing the medium without inconvenient residue

The PT-DDS4 media preparation and degassing system

The PT-DDS4 media preparation and degassing system

Why is Media Degassing so Important for a Successful Tablet Dissolution Test?

Media degassing or deaeration prevents the formation of bubbles due to dissolved air in the dissolution medium on the dosage form which can affect the dissolution test results.1 Media deaeration is required by the FDA (United States Food and Drug Administration) when dosage forms are sensitive to air bubbles. It has been shown that degassing systems working with the vacuum pump give the highest benefits.1

Deaerated vs. non-deaerated media – example one: Note the clean cone shape with the deaerated media on the left vs. the amount of flowing particles with the non-deaerated media on the right
Deaerated vs. non-deaerated media – example two with baskets: Note the air bubbles in the non-deaerated media on the right vs. no air bubbles on the deaerated media on the left

Deaerated vs. non-deaerated media – example one: Note the clean cone shape with the deaerated media on the left vs. the amount of flowing particles with the non-deaerated media on the right

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The PT-DDS4 is your reliable and handy lab companion for that. The media preparation instrument features standard gravimetric dosing for precise filling volumes at any working temperature – which is the preferred measurement by the USP for the Procedure for Mechanical Calibration and Performance Verification: “A more accurate and temperature independent measure of the medium volume is through weight”.

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1 USP <1092> and Effects of Deaeration Methods on Dissolution Testing in Aqueous Media; Gao et al. J Pharm Sci. 2006, 95, 1606–1613

PT-DDS4

PT-DDS4

Reliable and handy lab companion to effectively degas, heat and precisely dose dissolution media

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