Which system for online dissolution testing do you offer?
We supply semi-automated systems as well as fully automated dissolution solution packages. The latest invention is the IDS-1000 In-Situ Fiber Probe system. As the new DTS-800 its world-wide a unique design because all equipment needed to perform an automated dissolution test is "on board".
Which type of spectrophotometer can you control with the WinDiss ARGUS dissolution software?
There are many drivers validated and available, like: Agilent 8453 Diode Array, SA500 Diode Array, PTAG T60 + T70, Perkin Elmer Lambda, Analytic Jena Specord, Cecil 3000 - 7200, Varian Carry 50, Shimadzu, and others.
Is there a driver available to run Pharma Test dissolution baths with the Agilent ChemStation software?
Yes, we offer a driver for Agilent ChemStation, which can controls all Pharma Test baths.
Do you offer any suitable attachment for UV sensible drugs?
Yes, we supply amber coloured vessels.
What is special about your PT-DDS4 media degasser?
Some of unique features of the PT-DDS4 are: a built-in calibration program to qualify and calibrate the dosing accuracy - no need for any external balance. Of course the calibration and validation results are printed using the built-in printer. Dosing correction by entering the MEDIA DENSITY is a big advantage offered by the PT-DDS4. A dosing report is printed including information of the media and the dosed weight or volume.
Why do you offer a media preparation system with a 25 litre tank?
Most of the users of the PT-DDS4 dearation system produce the dissolution media in batches to fill media either into more than one dissolution bath or to use the dearated media for several tests. As the media can easily be stored in the tank, the time saving is a valid point. As is the reproducability of the media quality.
What is the major advantage of the new PTWS 100?
It is probably the smallest dissolution bath available and it can be placed in two different ways on your laboratory bench, making optimal use of the available space. The display and keyboard can be attached by the operator into a position which makes it easy for him to see and use it.
Do you supply qualification equipment and PVT standards?
Yes, we supply all necessary equipment to perform mechanical and chemical calibration of any dissolution bath, as well as corresponding certification.
What does "media refilling" or "media replacement" mean?
Media refilling means, that the system automatically replaces the medium which has been removed from the testing vessels while sampling with fresh medium for all vessels. The reason for this is that the Pharmacopeia allow only a very small change in the volume of the vessels for the total dissolution run. This means when a certain volume is sampled or you sample multiple times in one run (a dissolution profiling test) the sampled medium needs to be replaced. An alternative method is to mathematically correct the volume in the vessels to reflect the change after sampling. In most cases of automated dissolution systems, media refilling is used.
Where should the sample be removed?
Samples always have to be removed at the same position within a dissolution vessel: midways between liquid level and tool, not less than 1 cm off of the inner vessel wall. Pharma Test offers the PT-MDS sampling device for manual sampling to make sure the operator always complies to this requirement. In automated dissolution systems, the EPE automated sampling manifold will always drive to the same position during sampling.
What does "staggered start and sampling" mean?
„Staggered start and sampling“ means that the stirring will only start when the tablet is already inside the vessel and down at the spherical bottom. If the stirrers start earlier, the tablet may start to flow and rotate, which will change the dissolution speed.
„Staggered start and sampling“ instruments allow to start each stirring station individually. This means, the user can drop the 1st tablet and when it is down in the vessel, he starts the 1st stirring station. Now he waits for 30-60 seconds before starting the 2nd station, as this is the time he will need to withdraw a sample and refill the media. This process is repeated until all samples are inside the vessels.
Parallel start is possible for all automated dissolution systems, which are connected to a fraction collector, auto sampler or spectrophotometer with a multiple cell changer.
For what are the extra vessels in some dissolution testing instruments used?
The two extra vessels of PTWS 310, 610, 1210, D610 and PTWS 4000 can be used to take blank media (USP buffer or water) and/or a reference standard (pure active dissolved in the dissolution media).
What does MonoShaft mean?
All stirrers of Pharma Test tablet dissolution testing instruments are MonoShaft design versions: the stirring tool consists of one common stirring shaft to be used for every available stirring tool and an adapter with the appropriate length for a certain stirring tool (such as for example baskets). This means that the stirring shaft can always remain inside the instrument, while only the stirrer adapter (paddle, basket or transdermal cylinder) has to be exchanged when switching from one tool to another. Because of this, there is no need for the operator to qualify immersion depth after a change of tools. The joint of the MonoShaft stirrers always remains outside the medium.
Why should I think about automating my dissolution testing?
Dissolution testing is probably the most time and human resource consuming test in a pharmaceutical company. In manual operation usually the user has to be present at the instrument in order to take the samples within a narrow time frame with just +/- 2% of tolerance. This means if he has, for example, to remove a sample every 5 minutes, he should not be more than 6 Seconds early or late. To test sustained release tablets which may take 6 hours, 8 hours or up to several days (transdermal patches) is usually impossible to handle with manually operated equipment.